NewsHertz
📅 🕒 🌞DelhiLoading...

Beyond The Horizon

Health & Wellness

FDA Approves Vimseltinib for Tenosynovial Giant Cell Tumors

The U.S. Food and Drug Administration (FDA) has granted approval to Vimseltinib, a groundbreaking treatment for tenosynovial giant cell tumor (TGCT), offering new hope for patients battling this rare and debilitating condition. What is TGCT? Tenosynovial giant cell tumor is a rare, non-malignant tumor that affects the joints, tendons, and synovial lining, leading to pain, swelling, stiffness, and potential joint damage. While TGCT is not considered cancerous, its aggressive nature can significantly impact mobility and quality of life. Current treatment options include surgery and other targeted therapies, but recurrence remains a major concern for patients. Vimseltinib: A New Treatment Option Vimseltinib is an oral, small-molecule kinase inhibitor designed to target and inhibit colony-stimulating factor 1 receptor (CSF1R), a key driver of TGCT growth. By blocking CSF1R, Vimseltinib effectively reduces tumor size and alleviates symptoms, making it a promising alternative for patients who are not eligible for surgery or those experiencing tumor recurrence.  Clinical Trial Success The FDA’s approval is based on robust clinical trial data demonstrating Vimseltinib’s efficacy and safety. In pivotal trials, patients receiving Vimseltinib showed significant improvement in tumor reduction and symptom relief compared to the placebo group. The treatment also exhibited a favorable safety profile, with manageable side effects, including mild to moderate nausea, fatigue, and liver enzyme elevations. Vimseltinib Implications for Patients The approval of it marks a significant milestone in TGCT treatment, offering a non-surgical alternative for patients facing limited options. This breakthrough provides renewed optimism for those struggling with the condition, enhancing mobility and improving their overall quality of life. Future Outlook With ongoing research in targeted therapies, the approval of it underscores the potential of precision medicine in treating rare diseases. Experts believe that continued advancements in this field will further refine treatment approaches, ultimately benefiting patients with TGCT and other rare tumors. The availability of Vimseltinib signifies a crucial step forward in TGCT management, reinforcing the FDA’s commitment to approving innovative therapies for rare conditions. Patients and healthcare providers now have a new, effective option to combat this challenging disease.

A conceptual image illustrating the dangers of ultra-processed foods. On the left side, a table filled with generic fast food, chips, sugary drinks, and processed snacks, without any brand logos. On the right side, a human silhouette with a distressed expression, symbolizing health consequences such as obesity, fatigue, and poor mental health. The background contrasts vibrant artificial colors on the processed food side with a darker, cautionary tone on the health impact side."
Health & Wellness

The Hidden Dangers of Ultra-Processed Foods: Impact on Health and Longevity

Over the past few decades, ultra-processed foods have become a staple in many people’s diets. These foods, often marketed as convenient and delicious, are increasingly found in everyday meals. However, numerous studies in recent years have raised alarm over the health risks associated with consuming ultra-processed foods. These risks go beyond the obvious, with links to severe conditions such as high blood pressure, heart attacks, cancer, anxiety, dementia, and even early death. But what makes these foods so harmful, and how can we protect ourselves? What Are Ultra-Processed Foods? Ultra-processed foods are those that have been significantly altered through industrial processes, often involving the addition of artificial ingredients, preservatives, colors, sweeteners, and flavors. These foods are typically packaged and require little to no preparation. Examples include packaged snacks, sugary beverages, fast food, and ready-to-eat meals. These foods are designed for convenience and taste but often lack the essential nutrients our bodies need. They tend to be high in unhealthy fats, sugar, salt, and refined carbohydrates, all of which contribute to a wide range of health problems. The Surprising Health Risks Linked to Ultra-Processed Foods High Blood Pressure and Heart Attacks Consuming a diet high in ultra-processed foods has been linked to an increased risk of high blood pressure and heart disease. These foods often contain excessive levels of sodium and unhealthy fats, both of which can raise blood pressure and damage the cardiovascular system. In fact, a study published in JAMA Internal Medicine found that a higher intake of ultra-processed foods is associated with a greater risk of heart disease and stroke. Cancer A shocking finding from recent studies is the connection between ultra-processed foods and cancer. Research published in The BMJ showed that a diet rich in ultra-processed foods increases the risk of developing various types of cancer, including colorectal, breast, and prostate cancers. The additives and preservatives in these foods may contribute to inflammation and DNA damage, both of which are key factors in cancer development. Anxiety and Mental Health Issues The link between diet and mental health is becoming more evident, and ultra-processed foods are emerging as a major factor in mental health problems. Studies have found that diets high in processed foods are associated with an increased risk of anxiety, depression, and other mental health disorders. These foods can affect brain chemistry, disrupt gut health (which plays a crucial role in mental well-being), and increase inflammation—all of which can lead to anxiety and other mood disorders. Dementia and Cognitive Decline Another alarming consequence of consuming ultra-processed foods is the potential link to dementia and cognitive decline. A study published in Frontiers in Nutrition found that a high intake of ultra-processed foods may accelerate cognitive decline and increase the risk of developing conditions like Alzheimer’s disease. The high levels of refined sugars and fats in these foods can lead to insulin resistance and inflammation, both of which are known to contribute to brain aging and cognitive dysfunction. Early Death Perhaps the most shocking result from recent studies is the connection between ultra-processed foods and early death. A study conducted by the University of São Paulo found that the consumption of ultra-processed foods is associated with a higher risk of premature death. While the exact mechanisms are still under investigation, the accumulation of risks from heart disease, cancer, and other conditions may be the contributing factors. Why Are Ultra-Processed Foods So Harmful? The main reason ultra-processed foods are so harmful is their composition. These foods are often stripped of vital nutrients and packed with artificial ingredients that our bodies struggle to process. Here are a few reasons why they pose such a significant health risk: Nutrient Deficiency: Ultra-processed foods lack the vitamins, minerals, and fiber found in whole, unprocessed foods. This leads to deficiencies that can weaken the immune system and increase the risk of chronic diseases. High Sugar and Salt Content: Excessive sugar and salt consumption from ultra-processed foods can lead to high blood pressure, obesity, and metabolic syndrome, all of which are linked to a range of chronic health issues. Inflammation: Many artificial additives and preservatives in ultra-processed foods are known to cause inflammation in the body. Chronic inflammation is associated with numerous diseases, including heart disease, cancer, and dementia. Addiction: Ultra-processed foods are often engineered to be hyper-palatable, which means they trigger a reward response in the brain, leading to overeating and addiction-like behavior. This makes it difficult for individuals to break free from unhealthy eating patterns. How to Protect Yourself Given the overwhelming evidence of the risks posed by ultra-processed foods, it’s essential to take steps to protect your health. Here are some tips: Minimize Processed Foods: The best way to reduce your intake of ultra-processed foods is to cook more at home. Focus on whole, unprocessed foods such as fruits, vegetables, whole grains, lean proteins, and healthy fats. Read Labels: When you do buy packaged foods, be sure to read the labels carefully. Avoid products with long ingredient lists containing chemicals, preservatives, and artificial additives. Cook with Whole Ingredients: Instead of relying on ready-made meals, prepare your food from scratch using fresh, whole ingredients. This way, you control exactly what goes into your food. Limit Sugary Beverages: Sugary sodas and energy drinks are a major source of ultra-processed ingredients. Opt for water, herbal teas, or homemade smoothies instead. Mindful Eating: Pay attention to what you eat and how much. Mindful eating helps you become more aware of your food choices and encourages healthier habits. The evidence linking ultra-processed foods to serious health problems is undeniable. From heart disease to cancer, mental health issues to early death, the risks are far-reaching and severe. However, by being mindful of what we eat and making conscious choices to avoid ultra-processed foods, we can reduce these risks and live healthier, longer lives. Start making small changes today—your future self will thank you.

EpiBERT AI Model Predicts Gene Expression
Health & Wellness, Sci & Tech

EpiBERT AI Model Predicts Gene Expression Across Cells.

EpiBERT: AI Model Predicts Gene Expression Prediction AI Model Predicts Gene Expression is an AI model that can predict gene expression across various human cell types. It was developed by Dana-Farber Cancer Institute, The Broad Institute of MIT and Harvard, Google, and Columbia University. This tool is transforming how we understand gene regulation and its impact on diseases like cancer. How Does EpiBERT Work? EpiBERT builds on BERT, a deep learning model used in natural language processing. However, it focuses on genomic sequences and chromatin accessibility in human cells. EpiBERT trained on data from hundreds of human cell types, including 3 billion base pairs of genomic data and chromatin maps. Through this data, EpiBERT learned how chromatin accessibility influences gene expression. It can predict gene activation patterns in cells it has never encountered. This helps scientists identify regulatory elements that control gene activity. EpiBERT works similarly to models like ChatGPT. It builds a “grammar” of gene regulation across different cell types. This lets it predict gene activity in previously unstudied cells. Why EpiBERT Matters: Understanding Gene Regulation All cells share the same genetic code, but different cells express different genes. Around 20% of our genome contains regulatory elements that control which genes are turned on or off. Scientists have struggled to locate and understand how these elements work. EpiBERT solves this problem. It predicts gene activation in many different cell types. This insight is key for understanding diseases like cancer, where gene regulation goes awry and causes uncontrolled growth. EpiBERT and the Future of Disease Research EpiBERT could change how we approach genetic research. By understanding how genes are regulated and spotting mutations that affect gene function, EpiBERT can help diagnose diseases more accurately. It could also lead to better treatments for diseases like cancer. In the future, EpiBERT may enable precision medicine. It could predict how individual genetic profiles impact disease progression and treatment response. This would allow for more personalized, effective therapies. How EpiBERT Was Developed and Funded EpiBERT’s development was supported by organizations like The Broad Institute, Novo Nordisk Foundation, and the National Genome Research Institute. Google also contributed by providing access to Tensor Processing Units (TPUs), which helped train the model.  AI Model Predicts Gene  Impact on Genetic Research and Medicine EpiBERT is more than just a new AI tool. It’s a breakthrough in understanding gene regulation and its link to diseases like cancer. By predicting gene activity across human cell types, EpiBERT could unlock new avenues for genetic research, gene therapy, and personalized medicine. Key Takeaways: EpiBERT predicts gene expression across various human cell types. It trained on 3 billion base pairs of genomic data and chromatin maps.                                                                      EpiBERT helps us understand gene regulation, vital for disease research. By identifying mutations in regulatory elements, EpiBERT could lead to treatments for diseases like cancer. Google, The Broad Institute, and other organizations support the model. Next Steps for AI Model Predicts Gene As EpiBERT advances, it could transform our understanding of disease mechanisms. This could open up new possibilities for targeted therapies and precision medicine. To explore more, read the full study in Cell Genomics: Javed, N., et al. (2025). A multi-modal transformer for cell type-agnostic regulatory predictions. Cell Genomics. doi.org/10.1016/j.xgen.2025.100762.

Health & Wellness

Digital Eye Strain: Protecting Your Vision in the Screen Era

Digital Eye Strain Are your eyes feeling tired, dry, or irritated after long hours in front of a screen? You’re not alone. Digital eye strain, also known as computer vision syndrome, has become a common issue in our tech-driven world. In this article, we’ll explore what causes digital eye strain, its symptoms, and practical tips to protect your eyes in the screen era. Tailored especially for students, office workers, and avid gamers, this guide will help you reduce strain and safeguard your vision. What Is Digital Eye Strain? Digital eye strain refers to a group of eye and vision-related problems resulting from prolonged screen use. Whe ther it’s a computer, smartphone, or tablet, staring at a screen for extended periods can put immense stress on your eyes. Common Symptoms of Digital Eye Strain                                            Blurred vision Dry or irritated eyes Headaches Neck and shoulder pain Difficulty focusing on distant objects What Causes Digital Eye Strain? Several factors contribute to digital eye strain: Prolonged Focus on Screens: Focusing on close-up text or images for hours tires the eye muscles. Reduced Blinking: People tend to blink 50% less when using screens, leading to dry eyes. Poor Lighting: Glare and improper lighting can strain your eyes further. Blue Light Exposure: Screens emit blue light, which can disrupt sleep patterns and contribute to discomfort. 10 Tips to Protect Your Vision 1. Follow the 20-20-20 Rule Every 20 minutes, look at something 20 feet away for at least 20 seconds. This gives your eye muscles a break. 2. Adjust Your Screen Settings Increase text size for easy reading. Reduce screen brightness to match your surroundings. Use dark mode or blue light filters (more on this below). 3. Optimize Your Workspace Position your screen at eye level and about 20-28 inches away. Ensure your chair and desk setup promote good posture to reduce neck and shoulder strain. Keep your screen free of smudges to reduce glare and improve visibility. 4. Blink More Often Remind yourself to blink consciously to keep your eyes moist. 5. Use Artificial Tears Over-the-counter eye drops can help alleviate dryness and irritation. 6. Limit Screen Time Take frequent breaks and consider setting screen time limits, especially for children. 7. Invest in Blue Light Filters Blue light filters are a game changer for reducing eye strain. You can: Use built-in features on your devices, such as Night Shift on iPhones or Night Light on Windows and Android. Download apps like flux for additional blue light reduction. Consider blue light filtering glasses—an excellent option for students and office workers who spend 8+ hours on screens daily. 8. Adjust Lighting Conditions Avoid using screens in dark rooms and minimize glare by using anti-glare screen protectors. Use adjustable lighting to reduce contrast between your screen and the room’s brightness. 9. Get Regular Eye Checkups Visit an eye doctor annually to monitor your vision and address potential issues early. 10. Practice Good Habits Before Bedtime Avoid screens 1-2 hours before bed to reduce eye strain and improve sleep quality. Eye Exercises to Reduce Strain Incorporating eye exercises into your routine can alleviate strain and improve eye health: 1. Palming Technique Rub your hands together to warm them, then gently place your palms over your closed eyes for 1-2 minutes. This helps relax your eyes and reduce fatigue. 2. Focus Shifting Hold a pencil or your thumb at arm’s length. Focus on it, then shift your focus to something farther away. Repeat 10 times to strengthen your eye muscles. 3. Eye Rolling Gently roll your eyes in a circular motion for a few seconds. Repeat in the opposite direction. This can relieve tension and improve flexibility. 4. Figure 8 Exercise Imagine a giant figure 8 about 10 feet away. Trace it with your eyes slowly, alternating directions for 2 minutes. Ergonomic Considerations for Screen Use Creating an ergonomic workspace is essential for reducing digital eye strain, especially for office workers and students: Use a chair with proper lumbar support to maintain a healthy posture. Adjust your monitor height so the top of the screen is at or slightly below eye level. Keep your feet flat on the floor and your knees at a 90-degree angle. Use a document holder to avoid constantly shifting focus between printed materials and your screen. Why Addressing Digital Eye Strain Matters Ignoring digital eye strain can lead to long-term discomfort and vision problems. By implementing these strategies, you not only protect your eyes but also improve your productivity and overall well-being in the screen era. Conclusion Digital eye strain is an inevitable challenge in today’s screen-driven lifestyle, but it doesn’t have to compromise your vision. Tailored advice for students, office workers, and other screen users makes it easier to adopt effective habits. By incorporating small changes like adjusting your workspace, using blue light filters, and practicing eye exercises you can protect your vision and reduce discomfort. Start taking care of your eyes today—your vision is worth it!  

Health & Wellness

NATIONAL MYOPIA WEEK

NATIONAL MYOPIA WEEK: Raising Awareness for Healthier Vision in Children   This National Myopia Week, the MATANAND Welfare Foundation, in partnership with the Strabismus and Pediatric Ophthalmological Society of India (SPOSI), is committed to raising awareness about myopia—a growing eye health issue affecting millions of children worldwide. Myopia, also known as short-sightedness or “minus number” vision, makes it difficult to see distant objects clearly and often requires corrective lenses. Why Myopia Awareness Matters Myopia typically appears in childhood, starting as early as age 5 and often progressing until age 18. Currently, an estimated 1 in 4 children and teens in India have myopia, a prevalence that has surged from 4% in 1999 to 25% today. At this rate, it’s predicted that by 2050, half of all children and teens may be myopic. Children with untreated, moderate to severe myopia face an increased risk of serious eye health issues in adulthood, including early cataract development, glaucoma, and retinal detachment. Severe myopia may even restrict eligibility for certain vision correction surgeries like LASIK. Beyond the physical effects, myopia can impact a child’s cognitive development, academic performance, and social well-being. Taking Action for Our Children’s Vision The goal of National Myopia Week is to inform parents, caregivers, and the public about childhood myopia, its causes, and prevention. Studies show that encouraging outdoor play and reducing screen time can both prevent and slow the progression of myopia in children. Additionally, yearly eye exams are essential for early detection and treatment, giving children the best chance for a lifetime of healthy vision. Join the Movement: #AllEyesOnMyopia We invite everyone to be part of this awareness movement! Tag #AllEyesOnMyopia this #NationalMyopiaWeek and help spread the word about childhood myopia. Together, let’s protect our children’s vision and help them see a brighter future.

Scroll to Top